Short Communication Determination of CYP2D6 Gene Alleles by the CYP450 Probe Array Using the AŠymetrix GeneChip System: Comparison with Sequencing Results
نویسندگان
چکیده
We determined the CYP2D6 alleles in cell lines derived from 81 Japanese individuals with the CYP450 probe arrays using an AŠymetrix GeneChip apparatus. Sequencing of the CYP2D6 exons from these same cell lines was performed to determine the accuracy of the allele calls by the AŠymetrix probe array. Comparison of the results showed diŠerences in the data from three cell lines for the CYP2D6*10 alleles between these two methods. These results indicated that the CYP450 probe array must be utilized cautiously for typing CYP2D6*10 alleles, which are frequently observed in the Japanese population.
منابع مشابه
Comparison of two CYP2D6 genotyping methods and assessment of genotype-phenotype relationships.
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